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Thursday, May 7, 2020 | History

2 edition of study of the interaction between pseudomonas aeruginosa alginate and bronchial mucins. found in the catalog.

study of the interaction between pseudomonas aeruginosa alginate and bronchial mucins.

Yvonne Mary Smedley

study of the interaction between pseudomonas aeruginosa alginate and bronchial mucins.

by Yvonne Mary Smedley

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Published by Brighton Polytechnic Dept. of Pharmacy in [Brighton] .
Written in English


Edition Notes

Thesis (Ph.D.) - Brighton Polytechnic, 1986.

ContributionsBrighton Polytechnic. Department of Pharmacy.
ID Numbers
Open LibraryOL13866653M

  Pseudomonas aeruginosa is an opportunistic pathogen that causes chronic lung infections in people suffering from cystic fibrosis (CF). In CF airways, P. aeruginosa forms Cited by: Pseudomonas aeruginosa flagellin and alginate elicit very distinct gene expression patterns in airway epithelial cells: microarray analysis has shown that mucins inhibit the expression of flagellar genes [ Wolfgang M.C. Numerous in vivo and in vitro infection models have been used to study the interactions between PA and lung Cited by:

  Pseudomonas aeruginosa remains one of the most important bacterial pathogens in lung diseases and especially in Cystic fibrosis. This unusual predilection is best explained by the Cited by:   Pseudomonas aeruginosa in cystic fibrosis lung disease P. aeruginosa colonization of the airways and infection remain the most important contributor to CF morbidity and mortality. While the CFTR defect results in myriad respiratory problems for the patient, the most important clinical feature is the chronic pulmonary infection with P. by:

  The predominant mucins MUC5AC and MUC5B are overproduced in CF lung secretion, triggered by P. aeruginosa LPS. 51 Chronic infection with P. aeruginosa leads to a strong immune Cited by: 6. Abstract. Chronic lung infection with mucoid Pseudomonas aeruginosa is the major pathologic feature of cystic fibrosis. Previous studies suggested that a failure to produce opsonic antibody to the mucoid exopolysaccharide (MEP; also called alginate.


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Study of the interaction between pseudomonas aeruginosa alginate and bronchial mucins by Yvonne Mary Smedley Download PDF EPUB FB2

A study of the interaction between Pseudomonas aeruginosa alginate and bronchial mucins Author: Smedley, Y. ISNI: Awarding Body: Brighton Polytechnic Current. Purified Pseudomonas aeruginosa alginate stimulated mucin and lysozyme secretion in a dose-dependent fashion (mucin = +%: P = ; lysozyme = +20%: P = at microg/mL).

Pseudomonas aeruginosa and Staphylococcus aureus are versatile bacterial pathogens and common etiological agents in polymicrobial infections. Microbial communities containing both of these pathogens are shaped by interactions ranging from parasitic to mutualistic, with the net impact of these interactions Cited by:   P.

aeruginosa is an important nosocomial pathogen in patients with significant underlying diseases, and colonization is frequently selected by broad-spectrum antimicrobial usage (1, 2).In patients with damaged airways from mechanical ventilation, trauma, or antecedent viral infection, P.

aeruginosa colonization of the respiratory Cited by: Pseudomonas aeruginosa interactions promote biofilm formation and antibiotic resistance Rebecca M.

Landry, 1 In this study we begin to examine the effect of host polymers found in CF airways on P. aeruginosa human respiratory mucins. Biofilms of P. aeruginosa can become resistant to immune clearance and antimicrobial agents, threatening human health.

24,25,26 We used natively purified mucins for this study because Cited by: 8. Pseudomonas aeruginosa is an opportunistic pathogen that causes chronic lung infections in people suffering from cystic fibrosis (CF). In CF airways, P. aeruginosa forms surface-associated. Tsang et al. () have described a novel tissue culture model to study the interaction of Pseudomonas aeruginosa with adenoid tissue in which bacterial interaction with respiratory.

Introduction. Cystic fibrosis (CF) is an autosomal recessive disorder affecting 1 in live births in the UK [].This life-limiting condition (median predicted survival age ˜47 years) [] is the result of mutations in the CF transmembrane conductance regulator (CFTR) gene, characterized by impaired epithelial chloride transport, leading to an abnormally viscous mucous and poor lung Author: Manon F.

Pritchard, Juliette L. Oakley, Charles D. Brilliant, Philip D. Rye, Julian Forton, Iolo J.M. Alginate as an adhesin The strains of P. aeruginosa which are isolated from chronically infected CF patients are often phenotypically distinct from the strains which initiate infection.2 These strains are mucoid and produce large amounts of alginate Cited by: The long-term persistance of P.

aeruginosa in the cystic fibrosis (CF) lung is characterized by the selection of a variety of genotypes and phenotypes that typically descend from one infecting P. aeruginosa clone, a process known as adaptive radiation. This adaptation process of P. aeruginosa Cited by: Several functions of P.

aeruginosa alginate have been proposed, including mediation of bacterial adherence to tracheobronchial mucins of lung tissue (see Chapter 6), promotion of microcolony formation (see Chapter 5), defence against the host immune system (see Chapters 7 and 8), and protection from lung Cited by: The cystic fibrosis (CF) lung is chronically inflamed and infected by Pseudomonas aeruginosa, which is a major cause of morbidity and mortality in this genetic gh aerosolization of Tobramycin into the airway of CF patients improves outcomes, the lungs of CF patients, even those receiving antibiotic therapy, are persistently colonized by P.

by:   Pulmonary infections with Pseudomonas aeruginosa (PA) are a critical clinical concern for patients with cystic fibrosis (CF), 1, 2 with 95% of individuals colonized with the pathogen by the Cited by: A microtiter plate assay was developed to study the adherence of Pseudomonas aeruginosa to purified human tracheobronchial mucin.

The wells of the plates were treated with silicon to minimize. Experimental systems to study Pseudomonas aeruginosa (PA)–epithelial cell interactions.

In vivo, in vitro and model host systems that are being used to study PA –lung epithelial interactions. Genomic approaches to dissect the modulation of lung Cited by:   Initial experiments in this study sought to determine the impact of normoxia and anoxia upon the in vitro interactions between S.

aureus and CF clinical isolates of P. aeruginosa in Cited by: 2. INTRODUCTION. Pulmonary infections with Pseudomonas aeruginosa (PA) are a critical clinical concern for patients with cystic fibrosis (CF), 1,2 with 95% of individuals colonized with the pathogen Cited by: Alginate, a viscous polysaccharide from mucoid Pseudomonas aeruginosa, may interfere with the host defenses in patients with cystic fibrosis and chronic P.

aeruginosa lung infection. The alginate Cited by: Request PDF | Recognition of mucin components by Pseudomonas aeruginosa | Pseudomonas aeruginosa remains one of the most important bacterial pathogens in lung diseases and especially in.

Recent studies performed by Hoiby and colleagues show that treatment with azithromycin, which interferes with quorum sensing signaling, as well as alginate production, in vitro helps clear P.

aeruginosa from a mouse model of chronic lung infection. These data are consistent with a role for biofilm formation in the CF by: Mucins disassemble P. aeruginosa biofilms. To determine whether mucins affect the integrity of established biofilms, P. aeruginosa cells were grown in a previously characterized flow-cell system.

29 This flow-cell system permits continuous replenishment of mucins Cited by: 8.INTRODUCTION. Pseudomonas aeruginosa is an important opportunistic pathogen responsible for many nosocomial infections. Upon infection of the lungs of cystic fibrosis (CF) patients, it converts to a mucoid phenotype, characterized by the overproduction of the exopolysaccharide alginate Cited by: